AC1004: E64D

E64D is a cell permeable derivative of E64-C, an inhibitor of calpain and other cysteine proteases, such as papain, cathepsin B and cathepsin L. Addition of E64D to cell cultures should be done in serum-free media, as esterases in serum will cleave the ethyl ester and reduce cell permeability. Typical working concentration of E64D is 0.5-10 μg/ml. E64D inhibits degradation of autophagic cargo inside autolysosomes.

Info

Purity	98.0% by HPLC
Quantity	1 mg, 5 mg
Molecular Weight	342.4 g/mol
Physical State	Lyophilized white to off-white powder
Solubility	20 mg/mL in DMSO, 10mg/mL in ethanol
CAS No.	88321-09-9
Storage	-20°C, avoid freeze/thaw cycles