AC1002: 3-Methyladenine

3-Methyladenine inhibits autophagy by blocking autophagosome formation via inhibition of type III phosphatidylinositol 3-kinases (PI-3K). It protects 1321N1 astrocytoma cells against pyocyanin and hydroxyphenazine-induced toxicity. Inhibition of autophagy by 3-MA leads to enhanced apoptosis induced by a variety of agents including celastrol, cisplatin and sorafenib in several different cell lines.

Info

Purity	>98% by TLC
Quantity	25 mg, 50 mg, 100 mg
Molecular Weight	149.2 g/mol
Physical State	Lyophilized white powder
Solubility	3 mg/ml in DMSO; 10 mg/mL in warm DMF; 5 mg/mL in water
CAS No.	5142-23-4
Storage	-20°C, avoid freeze/thaw cycles