DUB Substrate Identification Services
Advanced proteomic solutions to identify deubiquitinase substrates and accelerate your drug discovery research
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- Overview
The Ubiquitin Proteasome System (UPS) controls the principal functions of almost all the cellular proteins of human cells and failures in this system often contribute directly or indirectly to the pathogenesis of many diseases, including cancer, inflammation, and neurodegeneration.
There are approximately 100 Deubiquitinases (DUBs) encoded in the human genome and the functions of most of these DUBs remain unknown. Identification of substrates of individual DUBs is an essential step to unravel cellular functions of DUBs.
Target Selection
Substrate Discovery
Validation & Analysis
- Advantages of Choosing LifeSensors For Your Drug Discovery Project
In Vitro & In Cell Assays
Comprehensive assays to identify DUB substrates in controlled environments and cellular contexts
Human Protein Array
Advanced TUBE technology enables identification of direct deubiquitination targets
Substrate Trapping & Proteomics
State-of-the-art proteomic analysis to identify endogenous substrates with precision
Orthogonal Validation
Rigorous validation of substrates through independent orthogonal assay methods
- Key Features
High-Throughput
High Precision
Fast Turnaround
- Product Catalog
- TUBEs
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