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SI9865: Tenovin 1

LifeSensors SI9865 (Tenovin 1) is a potent inhibitor of SirT1 and SirT2 deacetylase activity, stabilizing p53 by acetylation for cancer and aging research applications.

$146.00

SKU SI-9865-0010 Categories E1-E2-E3 Inhibitors, Small Molecule Modulators and PROTACs

In stock

Product Advantages

Applications

Studying the role of sirtuins in regulating cell growth

Tenovin 1 inhibits the deacetylase activity of SirT1 and SirT2. One of the substrates for SirT1 is p53 which is stabilized by acetylation of Lys-382. The ability of p53 to bind DNA is also enhanced by acetylation of Lys-382. Hence, inhibition of SirT1 by tenovin 1 leads to increased stability and activity of p53.

Info

Purity	99%; NMR consistent with structure
Quantity	10 mg
Molecular Weight	369.48 Da
Physical State	Powder
Solubility	200mM in DMSO
CAS No.	380315-80-0
Storage	4°C, (-20°C Long term). The product can be shipped at room temperature.

Datasheet

Datasheet

Applications

Studying the role of sirtuins in regulating cell growth

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