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Questions about a product, technology or experimental design? Give us a call 610-644-8845.
SI9619-5MG PR-619

SI9752: NMS-873

LifeSensors SI9752 (NMS-873) is an allosteric inhibitor targeting ATPase activity of AAA+ proteins, blocking protein extraction from the ER, used in advanced cellular research.

$250.00

In stock

In stock

p97 (aka VCP, Cdc48) is intimately involved in the ERAD process through the retrotranslocation of misfolded proteins targeted for degradation by the proteasome. It is a homohexamer of AAA+ ATPase subunits and ATP hydrolysis is required for protein extraction from the ER. NMS-873 is an allosteric inhibitor of ATPase activity, binding to the D1 and D2 domains of adjacent subunits (Magnaghi, D’Alessio et al. 2013). NMS-873 is reported to have an IC50 for p97 of 20-30nM.

Info

Purity 99% (TLC), NMR(conforms)
Quantity 5 mg
Molecular Weight 520.67 Da
Physical State Powder
Solubility 192mM in DMSO
CAS No. 1418013-75-8
Storage 4°C, (-20°C Long term). The product can be shipped at room temperature.

Applications

  • Inhibition of ERAD
  • Induction of apoptosis in cancer cells

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

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PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

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