Questions about a product, technology or experimental design? Give us a call 610-644-8845
Questions about a product, technology or experimental design? Give us a call 610-644-8845.

SI9752: NMS-873

LifeSensors SI9752 (NMS-873) is an allosteric inhibitor targeting ATPase activity of AAA+ proteins, blocking protein extraction from the ER, used in advanced cellular research.

$250.00

In stock

In stock

p97 (aka VCP, Cdc48) is intimately involved in the ERAD process through the retrotranslocation of misfolded proteins targeted for degradation by the proteasome. It is a homohexamer of AAA+ ATPase subunits and ATP hydrolysis is required for protein extraction from the ER. NMS-873 is an allosteric inhibitor of ATPase activity, binding to the D1 and D2 domains of adjacent subunits (Magnaghi, D’Alessio et al. 2013). NMS-873 is reported to have an IC50 for p97 of 20-30nM.

Info

Purity 99% (TLC), NMR(conforms)
Quantity 5 mg
Molecular Weight 520.67 Da
Physical State Powder
Solubility 192mM in DMSO
CAS No. 1418013-75-8
Storage 4°C, (-20°C Long term). The product can be shipped at room temperature.

Applications

  • Inhibition of ERAD
  • Induction of apoptosis in cancer cells

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

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All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

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All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

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PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

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