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Questions about a product, technology or experimental design? Give us a call 610-644-8845.

SI9840: TAME HCl

LifeSensors SI9840 (TAME HCl) inhibits the anaphase-promoting complex/cyclosome (APC/C), blocking Cdc20 and Cdh1 activation, stabilizing cyclin B1, used in cell-based assays.

$201.00

In stock

In stock

Inhibits the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C) by inhibiting binding and activation by the APC activators Cdc20 and Cdh1. TAME inhibits cyclin proteolysis in Xenopus extracts (IC50 = 12 µM) and inhibits Cdc20 association with APC at 200 µM. It stabilizes cyclin B1 by prematurely terminating ubiquitination. Substrate for trypsin, thrombin, plasmin, and other proteases.

Info

Purity >98% (TLC); NMR (Conforms)
Quantity 100 mg
Molecular Weight 378.9 Da
Physical State White Powder
Solubility May be dissolved in DMSO (35 mg/mL); or water (35 mg/mL)
CAS No. 1784-03-8
Storage 4°C, (-20°C Long term). The product can be shipped at room temperature.


Applications

  • Inhibition of the APC/C ubiquitin ligase.

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

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