SI9810: PYR-41 conjugating enzyme inhibitor

PYR-41 is a cell permeable, irreversible inhibitor of ubiquitin activating enzyme E1 with little or no activity against E2s or E3s (IC50 < 10 μM). It blocks degradation of p53 and inhibits NF-κB-dependent pathways. PYR-41 also increases SUMOylation of protein.

Info

Purity	> 98% (TLC); NMR (Conforms)
Quantity	10 mg, 25 mg, 50 mg
Molecular Weight	371.3 Da
Physical State	Brown powder
Solubility	DMSO (25mg/mL)
CAS No.	418805-02-4
Storage	4°C, (-20°C Long term). Store solutions at -20°C for up to one week. The product can be shipped at room temperature.