UB210T: UBE2D1, His6-SUMO

LifeSensors UB210T is a His6-SUMO tagged UBE2D1 enzyme, a 147 amino acid E2 ubiquitin-conjugating protein involved in targeting abnormal proteins for degradation.

$210.00 – $417.00

SKU UB-210T Categories E2 Ubiquitin Conjugating Enzymes, Ubiquitin Ligases and Enzymes

Product Advantages

Applications

Identify cognate E2/E3 pairs

Characterize upregulation/downregulation of E2 enzymes

Build poly-ubiquitin chains

Characterize ubiquitin chain specificity of E2 enzymes

Analyze expression of E2 enzymes

Benefits

Untagged (native) E2 conjugation enzyme

UBE2D1 is a 147 amino acid (16.6 kD) protein that mediates the degradation of abnormal proteins or proteins with short half-lives. It is a component of a Ubiquitin ligase complex including UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC, and TBL1X. It also functions in E6AP-mediated ubiquitylation of p53/TP53. UBE2D1 has been shown to interact with BARD1, UBE3A, and BRCA1.

Info

Species	Human
Source	E. coli
Tag	His₆-SUMO
Molecular Weight	28,621 Da (with tag)
Quantity	0.8 nmol, 3.0 nmol
Concentration	40 µM
Formulation	50 mM Tris pH 7.5, 150 mM NaCl, 10 mM DTT, 10% glycerol
Storage	-80°C, avoid freeze/thaw cycles