UM601: TUBE 1 (FLAG)

SKU UM-0601 Categories All, Pan-Selective TUBEs Tags Pan-selective, Pull down, Tandem Ubiquitin Binding entities

LifeSensors UM601 TUBE 1 (FLAG) offers up to 1000-fold higher affinity for isolating polyubiquitylated proteins, enhancing ubiquitin research without overexpressing tagged ubiquitins.

Price range: $575.00 through $1,799.00

Based on UBA domains known to possess a high affinity for ubiquitin, Tandem Ubiquitin Binding Entities (TUBEs) have been developed for the isolation and identification of ubiquitinated proteins. TUBEs display up to a 1000-fold increase in affinity for polyubiquitin moieties over the single ubiquitin binding associated domain (UBA). In addition, TUBEs have been demonstrated to protect polyubiquitinated proteins from both deubiquitination and proteasome-mediated degradation, allowing for the detection of relatively low abundant proteins that cannot be detected with current technologies. This product is protected by one or more US or Foreign patents. Please read the Limited Use Label License to learn more. By purchasing this product, the purchaser agrees to comply with these terms.

Info

Tag	FLAG
Molecular Weight	28.2 kDa
Physical State	Liquid
Quantity	200 µg and 1 mg
Concentration	Variable
Storage	-80°C, avoid freeze/thaw cycles

Datasheet
Manual

Applications

Pull down of poly-ubiquitylated proteins from cell and tissue lysates
Protection of poly-ubiquitylated proteins from both deubiquitylation and degradation by the proteasome

Benefits

Up to 1000-fold higher affinity than the single UBA domain
Avoid overexpression of affinity-tagged ubiquitins for pull downs
Protect poly-ubiquitin chains without inhibitors specific to the proteasome or deubiquitylase activity
Replace ubiquitin specific antibodies for enrichment of poly-ubiquitylated proteins

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

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UM601: TUBE 1 (FLAG)

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