Questions about a product, technology or experimental design? Give us a call 610-644-8845
Questions about a product, technology or experimental design? Give us a call 610-644-8845.

UB221: UBE2S

LifeSensors UB221 is a high-quality E2 ubiquitin-conjugating enzyme (UBE2S) used in research to study ubiquitination pathways, protein degradation, and cellular regulation.

Price range: $196.00 through $390.00

UBE2S (also known as E2-24K or E2-EPF) is an E2 conjugating enzyme that is involved in the ubiquitylation of target substrates along with E1 and E3 enzymes. It has been implicated in the ubiquitylation of anaphase-promoting complex (APC/C), promoting the elongation of K11-linked polyubiquitin chains on this substrate, after initial ubiquitylation by either UBE2C or UBE2D1. This polyubiquitin chain elongation enhances the degradation of APC/C by the proteasome. UBE2S also targets von Hippel-Lindau (VHL) for proteasome degradation, resulting in the stabilization of HIF-1a.

Info

Species Human
Source E. coli
Tag None
Molecular Weight 23,845.7 Da
Quantity 0.8 nmol, 3.0 nmol
Concentration 40 µM
Formulation 20 mM Tris pH 7.4, 150 mM NaCl, 10% glycerol, 10 mM DTT
Storage -80°C, avoid freeze/thaw cycles
  • Identify cognate E2/E3 pairs
  • Characterize upregulation/downregulation of E2 enzymes
  • Build poly-ubiquitin chains
  • Characterize ubiquitin chain specificity of E2 enzymes
  • Analyze expression of E2 enzymes

Benefits

  • Untagged (native) E2 conjugation enzyme

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

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