UB216: UBE2F

LifeSensors UB216 is the UBE2F E2 ubiquitin conjugating enzyme, essential for targeted ubiquitylation in protein regulation, available for advanced biochemical research.

$245.00 – $439.00

SKU UB-0216 Categories E2 Ubiquitin Conjugating Enzymes, Ubiquitin Ligases and Enzymes

Product Advantages

Applications

Identify cognate E2/E3 pairs
Characterize upregulation/downregulation of E2 enzymes
Build poly-ubiquitin chains
Characterize ubiquitin chain specificity of E2 enzymes
Analyze expression of E2 enzymes

Benefits

Untagged (native) E2 conjugation enzyme

UBE2F is an E2 conjugation enzyme that is involved in the ubiquitylation of target substrates, along with E1 and E3 enzymes. UBE2F mediates the transfer of NEDD8 from NEDD8-activating enzyme E1 (UBA3-NAE1 complex) to a substrate protein. This E2 enzyme has been shown to associate with the both NEDD8 E3 ligase and RBX2, yet displays different target cullin specificities than a similar UBE2M/RBX1 E2/E3 complex.

Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	21,077.4 Da
Quantity	0.8 nmol, 3.0 nmol
Concentration	Variable
Formulation	20 mM Tris pH 7.4, 150 mM NaCl, 10 mM DTT, 10% glycerol
Storage	-80°C, avoid freeze/thaw cycles