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SI9845: SKPin C1

LifeSensors SI9845 (SKPin C1) is a selective inhibitor of Skp2-mediated p27 degradation, inducing p27 accumulation and cell cycle arrest, used in cancer research and Skp2 studies.

$159.00

SKU SI-9845-0005 Categories E1-E2-E3 Inhibitors, Small Molecule Modulators and PROTACs

In stock

Product Advantages

Applications

Cell-based and in vitro studies of Skp2 function.

Inhibits the cullin-RING ubiquitin E3 ligase SCF-Skp2. Selectively inhibits Skp2-mediated p27 degradation by reducing p27 binding. In cancer cells, the compound induces p27 accumulation and promotes cell type-specific blocks in G1 or G2/M phases.

Info

Purity	98% by TLC; NMR (conforms)
Quantity	5 mg
Molecular Weight	465.34 Da
Physical State	Lyophilized solid
Solubility	DMSO (58mg/ml); Ethanol (8mg/ml); Water (<1mg/ml)
CAS No.	432001-69-9
Storage	Store desiccated as supplied at 4ºC; Product can be shipped at room temperature.

Datasheet

Datasheet

Applications

Cell-based and in vitro studies of Skp2 function.

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