Questions about a product, technology or experimental design? Give us a call 610-644-8845
Questions about a product, technology or experimental design? Give us a call 610-644-8845.

SI9865: Tenovin 1

LifeSensors SI9865 (Tenovin 1) is a potent inhibitor of SirT1 and SirT2 deacetylase activity, stabilizing p53 by acetylation for cancer and aging research applications.

$146.00

In stock

In stock

Tenovin 1 inhibits the deacetylase activity of SirT1 and SirT2. One of the substrates for SirT1 is p53 which is stabilized by acetylation of Lys-382. The ability of p53 to bind DNA is also enhanced by acetylation of Lys-382. Hence, inhibition of SirT1 by tenovin 1 leads to increased stability and activity of p53.

Info

Purity 99%; NMR consistent with structure
Quantity 10 mg
Molecular Weight 369.48 g/mol, alternative Daltons
Physical State Powder
Solubility 200mM in DMSO
CAS No. 380315-80-0
Storage 4°C, (-20°C Long term). The product can be shipped at room temperature.

Applications

  • Studying the role of sirtuins in regulating cell growth

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

Available Monday – Friday, 9:00 AM – 5:00 PM EST
We typically respond within 24 hours

Visit Anytime

271 Great Valley Parkway Malvern, PA 19355

Send us a Message

Have a question about our solutions? We’d love to hear from you.
* Required fields

More from This Category

LifeSensors SI9815 is a high-purity ubiquitin protein used in biochemical research to study ubiquitination processes and protein degradation pathways.....
LifeSensors SI9890 (AT-406) is an oral Smac mimetic that inhibits apoptosis proteins XIAP, cIAP1, and cIAP2, showing potential in cancer....
LifeSensors SI9855 (PTC-209) selectively reduces BMI-1 protein levels, impacting chromatin remodeling and gene repression, used for studying BMI-1 function in....
LifeSensors SI9619 (PR-619) is a cell-permeable, reversible, non-selective inhibitor of deubiquitinases and ubiquitin-like isopeptidases, inducing ubiquitin and SUMO protein accumulation....

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Menu

Learning Center