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Questions about a product, technology or experimental design? Give us a call 610-644-8845.

SI9865: Tenovin 1

LifeSensors SI9865 (Tenovin 1) is a potent inhibitor of SirT1 and SirT2 deacetylase activity, stabilizing p53 by acetylation for cancer and aging research applications.

$146.00

In stock

In stock

Tenovin 1 inhibits the deacetylase activity of SirT1 and SirT2. One of the substrates for SirT1 is p53 which is stabilized by acetylation of Lys-382. The ability of p53 to bind DNA is also enhanced by acetylation of Lys-382. Hence, inhibition of SirT1 by tenovin 1 leads to increased stability and activity of p53.

Info

Purity 99%; NMR consistent with structure
Quantity 10 mg
Molecular Weight 369.48 g/mol, alternative Daltons
Physical State Powder
Solubility 200mM in DMSO
CAS No. 380315-80-0
Storage 4°C, (-20°C Long term). The product can be shipped at room temperature.

Applications

  • Studying the role of sirtuins in regulating cell growth

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

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PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

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