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SI9855: PTC-209

LifeSensors SI9855 (PTC-209) selectively reduces BMI-1 protein levels, impacting chromatin remodeling and gene repression, used for studying BMI-1 function in cancer research.

$225.00

SKU SI-9855-0005 Categories E1-E2-E3 Inhibitors, Small Molecule Modulators and PROTACs

In stock

Product Advantages

Applications

Studying the function of BMI-1

Treatment of cells with PTC-209 leads to the selective reduction in the levels of BMI-1 protein (Kreso, van Galen et al. 2014). BMI-1 is a component of the polycomb PRC complex and interacts directly with the E3 ligase RING1A and/or RING2. The PRC complex mediates monoubiquitylation of histone H2A on Lys-119 and is involved in chromatin remodeling and repression of gene expression.

Info

Purity	99%; NMR consistent with structure
Quantity	5 mg
Molecular Weight	576.1 Da
Physical State	Powder
Solubility	173mM in DMSO
CAS No.	1217022-63-3
Storage	4°C, (-20°C Long term). The product can be shipped at room temperature.

Datasheet

Datasheet

Applications

Studying the function of BMI-1

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