Questions about a product, technology or experimental design? Give us a call 610-644-8845
Questions about a product, technology or experimental design? Give us a call 610-644-8845.

SI9725: MLN2238

LifeSensors SI9725 (MLN2238) is a selective, reversible proteasome inhibitor targeting the chymotrypsin-like β5 site, used in cancer research and drug discovery.

$310.00

In stock

In stock

MLN2238 is a proteasome inhibitor. Much like Bortezomib, MLN2238 selectively and reversibly inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome, with IC50 and Ki of 3.4 nM and 0.93 nM, respectively. MLN9708 is the prodrug form of MLN2238; the two compounds are also known as ixazomib citrate and ixazomib, respectively. Under physiological conditions, the boronic citrate ester is rapidly hydrolyzed to a boronic acid. Ixazomib has been used in combination therapy as a treatment for multiple myeloma, and studies indicate that it has the potential to treat other cancers as well.

Info

Purity >99% (HPLC), NMR (conforms)
Quantity 5 mg
Molecular Weight 361.03 Da
Physical State Lyophilized powder
Solubility DMSO (72 mg/mL); ethanol (9 mg/mL)
CAS No. 1072833-77-2
Storage 4°C, (-20°C Long term). The product can be shipped at room temperature.

Applications

  • Inhibition of chymotrypsin-like proteasome catalytic activity.
  • Cellular studies of proteasome inhibition.

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

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PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

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