SI9720: PS-341

PS-341 (Pyz-Phe-boroLeu) is the active ingredient in Bortezomib (Velcade). PS-341 is a reversible, cell-permeable, potent, and selective proteasome inhibitor (Ki = 0.6 nM). It binds the catalytic site of the 26S proteasome with high affinity and specificity. Inhibits proliferation of a number of tumor cell lines (IC50 = 7 nM). Inhibits TNF synthesis and FGF-induced angiogenesis.

Info

Purity	>98% (HPLC), NMR (conforms)
Quantity	5 mg, 25 mg
Molecular Weight	384.24 Da
Physical State	White powder
Solubility	DMSO (76 mg/mL)
CAS No.	179324-69-7
Storage	4°C, (-20°C Long term). The product can be shipped at room temperature.