Specifications
PS-341 (Pyz-Phe-boroLeu) is the active ingredient in Bortezomib (Velcade). PS-341 is a reversible, cell-permeable, potent, and selective proteasome inhibitor (Ki = 0.6 nM). It binds the catalytic site of the 26S proteasome with high affinity and specificity. Inhibits proliferation of a number of tumor cell lines (IC50 = 7 nM). Inhibits TNF synthesis and FGF-induced angiogenesis.
Info
| Purity | >98% (HPLC), NMR (conforms) |
| Quantity | 5 mg, 25 mg |
| Molecular Weight | 384.24 Da |
| Physical State | White powder |
| Solubility | DMSO (76 mg/mL) |
| CAS No. | 179324-69-7 |
| Storage | 4°C, (-20°C Long term). The product can be shipped at room temperature. |
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