Questions about a product, technology or experimental design? Give us a call 610-644-8845
Questions about a product, technology or experimental design? Give us a call 610-644-8845.

SI9699: P22077 Inhibitor

LifeSensors SI9699 is a potent, cell-permeable inhibitor targeting deubiquitinases, aiding research in protein regulation and degradation with high efficacy.

Price range: $159.00 through $566.00

P22077 is a cell-permeable inhibitor of the ubiquitin-specific protease USP7 (IC50 = 8.6 ÎĽM), and the closely related deubiquitinase (DUB) USP47. P22077 showed weak or no inhibition (EC50 > 50 ÎĽM) towards a panel of 14 isopeptidases and other proteases. Treatment of cells with P22077 (20-40 ÎĽM) causes an accumulation of K48-linked ubiquitinated species, and downregulation of the USP7 targets HDM2 and claspin.

Info

Purity >98% (HPLC), NMR (conforms)
Quantity 10 mg, 50 mg
Molecular Weight 315.3 Da
Physical State Light powder
Solubility DMSO
CAS No. 1247819-59-5
Storage 4°C, (-20°C Long term). Store solutions at -20°C for up to one month.  The product can be shipped at room temperature.
  • Inhibition of USP7 and USP47 activity.

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

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PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

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