SI9669: b-AP15

SKU SI-9669 Categories DUB inhibitors, Proteasome Inhibitors, Small Molecule Modulators and PROTACs

LifeSensors SI9669 is a specialized ubiquitin reagent designed for advanced research in protein regulation and ubiquitination pathways, supporting precise biochemical studies.

Price range: $80.00 through $377.00

Blocks 26S proteasome activity by inhibiting the ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) activities of the 19S regulatory subunit without affecting the catalytic activity of the 20S core subunit. b-AP15 displays several differences to bortezomib including insensitivity to over-expression of the anti-apoptotic mediator Bcl-2 and anti-tumor activity in four solid tumor models.

Info

Purity	>98% (TLC), NMR (conforms)
Quantity	5 mg, 25 mg
Molecular Weight	419.4 Da
Physical State	Pale yellow powder
Solubility	DMSO (35 mg/mL)
CAS No.	1009817-63-3
Storage	4°C, (-20°C Long term). The product can be shipped at room temperature.

Datasheet

Applications

Validation studies of the deubiquitinating activities of the 19S regulatory particle as a drug target
Cell-based and in vitro characterization of UCH-L5 or USP14 activity
Inhibition of the 26S proteasome through a mechanism distinct from inhibition of 20S catalytic activity

Benefits

D’Arcy P. et al. Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nature Medicine 2011 17:1636
D’Arcy P. and Linder S. Proteasome deubiquitinases as novel targets for cancer therapy. Int. J. Biochem. Cell Biol. 2012 E Published ahead of print.

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

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SI9669: b-AP15

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