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Questions about a product, technology or experimental design? Give us a call 610-644-8845.
SI9619-5MG PR-619

SI9659: WP-1130

WP1130, derived from the tyrphostin AG490, was identified in a screen for molecules that suppress IL-3 and IL-6 activation.

Price range: $213.00 through $541.00

A partially-selective DUB inhibitor that directly inhibits USP9x, USP5, USP14, and UCH37. WP1130, derived from the tyrphostin AG490, was identified in a screen for molecules that suppress IL-3 and IL-6 activation of STAT molecules. It has been subsequently shown to induce rapid accumulation of polyubiquitinated (K48/K63-linked) proteins into juxtanuclear aggresomes, block JAK2 signaling through JAK2 ubiquitination and subsequent downregulation, and exhibit antiviral activity through activation of the unfolded protein response (UPR). The typical concentration for cell culture experiments is 5 µM.

Info

Purity >98% (TLC), NMR (conforms)
Quantity 5 mg, 25 mg
Molecular Weight 384.3 Da
Physical State Pale yellow powder
Solubility DMSO (45 mg/mL); ethanol (25 mg/mL)
CAS No. 126288-28-7
Storage 4°C, (-20°C long term). This product can be shipped at room temperature.

Applications

  • Cell-based studies of USP function.
  • Benefits: cell-permeable.

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

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All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

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