SI9659: WP-1130

LifeSensors SI9659 is a K6-linked tetra-ubiquitin chain, used for studying ubiquitin signaling and protein degradation, enabling advanced research in cellular regulation pathways.

$213.00 – $541.00

SKU SI-9659 Categories DUB inhibitors, Small Molecule Modulators and PROTACs

Product Advantages

Applications

Cell-based studies of USP function.
Benefits: cell-permeable.

A partially-selective DUB inhibitor that directly inhibits USP9x, USP5, USP14, and UCH37. WP1130, derived from the tyrphostin AG490, was identified in a screen for molecules that suppress IL-3 and IL-6 activation of STAT molecules. It has been subsequently shown to induce rapid accumulation of polyubiquitinated (K48/K63-linked) proteins into juxtanuclear aggresomes, block JAK2 signaling through JAK2 ubiquitination and subsequent downregulation, and exhibit antiviral activity through activation of the unfolded protein response (UPR). The typical concentration for cell culture experiments is 5 µM.

Info

Purity	>98% (TLC), NMR (conforms)
Quantity	5 mg, 25 mg
Molecular Weight	384.3 Da
Physical State	Pale yellow powder
Solubility	DMSO (45 mg/mL); ethanol (25 mg/mL)
CAS No.	126288-28-7
Storage	4°C, (-20°C long term). This product can be shipped at room temperature.