Questions about a product, technology or experimental design? Give us a call 610-644-8845
Questions about a product, technology or experimental design? Give us a call 610-644-8845.

SI9659: WP-1130

LifeSensors SI9659 is a K6-linked tetra-ubiquitin chain, used for studying ubiquitin signaling and protein degradation, enabling advanced research in cellular regulation pathways.

Price range: $213.00 through $541.00

A partially-selective DUB inhibitor that directly inhibits USP9x, USP5, USP14, and UCH37. WP1130, derived from the tyrphostin AG490, was identified in a screen for molecules that suppress IL-3 and IL-6 activation of STAT molecules. It has been subsequently shown to induce rapid accumulation of polyubiquitinated (K48/K63-linked) proteins into juxtanuclear aggresomes, block JAK2 signaling through JAK2 ubiquitination and subsequent downregulation, and exhibit antiviral activity through activation of the unfolded protein response (UPR). The typical concentration for cell culture experiments is 5 µM.

Info

Purity >98% (TLC), NMR (conforms)
Quantity 5 mg, 25 mg
Molecular Weight 384.3 Da
Physical State Pale yellow powder
Solubility DMSO (45 mg/mL); ethanol (25 mg/mL)
CAS No. 126288-28-7
Storage 4°C, (-20°C long term). This product can be shipped at room temperature.

Applications

  • Cell-based studies of USP function.
  • Benefits: cell-permeable.

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

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PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

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