SI0603P: K6-Linked Tri-Ubiquitin (Phosphorylated)

SKU SI-0603P-0025 Categories All, Phosphorylated Ubiquitin Chains, Ubiquitin and Neuro-degeneration, Ubiquitin Chains and Derivatives, Ubiquitin Derivatives Tag Linkage-specific

LifeSensors’ SI0603P: K6-Linked Tri-Ubiquitin (Phosphorylated) is a trimeric chain of wild-type ubiquitin, useful in proteomics research

$695.00

K6-linked ubiquitination is traditionally associated with mitophagy and also a main contributor to the DNA damage response. These chain types are also involved in protein stabilization and other non-degradative processes. Phospho-ubiquitin chains represent a specialized class of polyubiquitin characterized by phosphorylation at Serine 65 and play a central role in mitophagy signaling pathways. K6 Tri-Ubiquitin (phosphorylated) is a trimeric chain of wild-type ubiquitin, wherein ubiquitin monomers are enzymatically linked together via an isopeptide bond between Lysine 6 and the C-terminal Glycine. The chains are then enzymatically phosphorylated at the Ser65 position.

Species	Human
Source	E. coli
Tag	None
Molecular Weight	25766-25926 Da (depending on degree of phosphorylation)
Quantity	25µg
Concentration	Variable
Formulation	20 mM Tris pH 7.5, 150 mM NaCl
Storage	-80°C, avoid freeze/thaw cycles

Datasheet

Investigation of phospho-ubiquitin chain specificity and selectivity
Studies on the role of phospho-ubiquitin chains in protein degradation pathways (e.g., proteasomal and autophagic degradation)
Analysis of phospho-ubiquitin-mediated signaling pathways and cellular responses
Structural studies to elucidate the architecture and dynamics of phospho-ubiquitin chains
Screening assays to identify modulators of phospho-ubiquitin chain assembly and disassembly processes

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

Phone (Office)

610.644.8845

Available Monday – Friday, 9:00 AM – 5:00 PM EST

Send Email

info@lifesensors.com

We typically respond within 24 hours

Visit Anytime

271 Great Valley Parkway Malvern, PA 19355

Send us a Message

Have a question about our solutions? We’d love to hear from you.

First Name *

Last Name *

Email Address *

Phone Number

Company/Organization

Subject*

Message *

I would like to receive updates about new products and research developments

* Required fields

Custom Solutions

Learning Center

SI0603P: K6-Linked Tri-Ubiquitin (Phosphorylated)

Follow Us

Send us a Message

More from This Category

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Menu

Custom Solutions

Learning Center