Ubiquitin Proteasome System, E1 E2 E3 Ligase

K6 Tetra-Ubiquitin (Ub4) (S20C) Mutant

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SKU: SI-0624 Categories: , , Tags: ,

Specifications

Mitophagy (the autophagic processing of damaged mitochondria) via Parkin activation is mainly promoted by K6 and K63 linked chains.  K6-linked ubiquitination is also a main contributor to the DNA damage response and acts as a DNA-binding enhancer during the innate immune system response.  These chain types are also involved in protein stabilization and other non-degradative processes. The serine in position 20 has been changed to a cysteine.

These tetra-ubiquitin chains are generated from the enzymatic linkage of wild-type ubiquitin through lysine 6.

Product Information

Purity ≥ 70% SDS-PAGE and Mass Spectrometry
Molecular Weight 34267 Da
Physical State Liquid
Quantity 25 µg or 50 µg
Solubility >30 mg/ml
Storage -80°C, avoid freeze/thaw cycles

Additional information

Size

25 µg, 50 µg

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Application

  • To investigate enzymes that cleave this specific peptide linkage between two ubiquitin molecules.
  • To better understand the mechanisms of ubiquitin-activating (E1) or ubiquitin-conjugating (E2) enzymes, ubiquitin-associated domains (UBA), or ubiquitin-interacting motifs (UIMs) among others.
  • To use as a label through biotinylation or fluorescence.

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