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AC2005: 17-AAG

Lifesensors AC2005 (17-AAG) is a potent HSP90 inhibitor with 100x higher affinity for tumor cells, used as an autophagy modulator in cancer research and therapy.

$69.00 – $171.00

SKU AC-2005 Categories Autophagy Inducers, Autophagy Modulators, Small Molecule Modulators and PROTACs

Product Advantages

Tanespimycin (17-AAG) is a cell permeable, less toxic and more stable semi-synthetic analog of geldanamycin. 17-AAG is a potent HSP90 inhibitor displaying a 100-fold higher affinity for tumor cell derived HSP90 over normal cell HSP90. 17-AAG displays anti-angiogenic activity and sensitizes tumor cells to apoptosis in response to such agents as taxol and cisplatin. Tanespimycin (17-AAG) depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin (17-AAG) also downregulates stk38 gene expression.

Info

Purity	>98% by TLC
Quantity	1 mg, 5 mg
Molecular Weight	585.7 g/mol
Physical State	Lyophilized red to dark red powder
Solubility	>50 mg/ml in DMSO; 5 mg/mL in ethanol
CAS No.	75747-14-7
Storage	-20°C, avoid freeze/thaw cycles

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