Specifications
Tanespimycin (17-AAG) is a cell permeable, less toxic and more stable semi-synthetic analog of geldanamycin. 17-AAG is a potent HSP90 inhibitor displaying a 100-fold higher affinity for tumor cell derived HSP90 over normal cell HSP90. 17-AAG displays anti-angiogenic activity and sensitizes tumor cells to apoptosis in response to such agents as taxol and cisplatin. Tanespimycin (17-AAG) depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin (17-AAG) also downregulates stk38 gene expression.
Info
| Purity | >98% by TLC |
| Quantity | 1 mg, 5 mg |
| Molecular Weight | 585.7 g/mol |
| Physical State | Lyophilized red to dark red powder |
| Solubility | >50 mg/ml in DMSO; 5 mg/mL in ethanol |
| CAS No. | 75747-14-7 |
| Storage | -20°C, avoid freeze/thaw cycles |
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