Questions about a product, technology or experimental design? Give us a call 610-644-8845
Questions about a product, technology or experimental design? Give us a call 610-644-8845.

AC2005: 17-AAG

LifeSensors AC2005 (17-AAG) is a potent HSP90 inhibitor with 100x higher affinity for tumor cells, used as an autophagy modulator in cancer research and therapy.

Price range: $69.00 through $171.00

Tanespimycin (17-AAG) is a cell permeable, less toxic and more stable semi-synthetic analog of geldanamycin. 17-AAG is a potent HSP90 inhibitor displaying a 100-fold higher affinity for tumor cell derived HSP90 over normal cell HSP90. 17-AAG displays anti-angiogenic activity and sensitizes tumor cells to apoptosis in response to such agents as taxol and cisplatin. Tanespimycin (17-AAG) depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin (17-AAG) also downregulates stk38 gene expression.

Info

Purity >98% by TLC
Quantity 1mg, 5mg
Molecular Weight 585.7 g/mol
Physical State Lyophilized red to dark red powder
Solubility >50 mg/ml in DMSO; 5 mg/mL in ethanol
CAS No. 75747-14-7
Storage -20°C, avoid freeze/thaw cycles

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

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PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

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