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Questions about a product, technology or experimental design? Give us a call 610-644-8845.

AC1008: Xanthohumol

LifeSensors AC1008 is a potent xanthohumol-based autophagy modulator designed for advanced research in cellular pathways and therapeutic development.

Price range: $159.00 through $472.00

Xanthohumol binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of VCP thereby impairing autophagosome maturation resulting in accumulation of the microtubule-associated protein 1 light chain 3-II (LC3-II). It also impairs prostate cancer cell growth and proliferation. Xanthohumol suppresses the growth of pancreatic cancer cells via down-regulation of Notch1 signaling. Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects.

Info

Purity >98% by TLC
Quantity 5mg, 25mg
Molecular Weight 354.4 g/mol
Physical State Lyophilized yellow powder
Solubility 35 mg/mL in DMSO or ethanol
CAS No. 6754-58-1
Storage -20°C, avoid freeze/thaw cycles

Impairs autophagosome maturation

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

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PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

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