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AC1008: Xanthohumol

Lifesensors AC1008 is a potent xanthohumol-based autophagy modulator designed for advanced research in cellular pathways and therapeutic development.

$159.00 – $472.00

SKU AC-1008 Categories Autophagy Inhibitors, Autophagy Modulators, Small Molecule Modulators and PROTACs

Product Advantages

Impairs autophagosome maturation

Xanthohumol binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of VCP thereby impairing autophagosome maturation resulting in accumulation of the microtubule-associated protein 1 light chain 3-II (LC3-II). It also impairs prostate cancer cell growth and proliferation. Xanthohumol suppresses the growth of pancreatic cancer cells via down-regulation of Notch1 signaling. Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects.

Info

Purity	>98% by TLC
Quantity	5 mg, 25 mg
Molecular Weight	354.4 g/mol
Physical State	Lyophilized yellow powder
Solubility	35 mg/mL in DMSO or ethanol
CAS No.	6754-58-1
Storage	-20°C, avoid freeze/thaw cycles

Datasheet

Datasheet

Impairs autophagosome maturation

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