UB210: UBE2D1

LifeSensors UB210 is a purified UBE2D1 E2 ubiquitin-conjugating enzyme essential for mediating protein degradation via the ubiquitin-proteasome system, widely used in research on protein regulation and degradation pathways.

$245.00 – $487.00

SKU UB-0210 Categories E2 Ubiquitin Conjugating Enzymes, Ubiquitin Ligases and Enzymes

Product Advantages

Applications

Identify cognate E2/E3 pairs
Characterize upregulation/downregulation of E2 enzymes
Build poly-ubiquitin chains
Characterize ubiquitin chain specificity of E2 enzymes
Analyze expression of E2 enzymes

Benefits

Untagged (native) E2 conjugation enzyme

UBE2D1 is a 147 amino acid protein that mediates degradation of abnormal proteins or proteins with short half-lives. It is a component of a Ubiquitin ligase complex including UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC, and TBL1X. It also functions in E6AP mediated ubiquitylation of p53/TP53. UBE2D1 has been shown to interact with BARD1, UBE3A, and BRCA1.

Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	16,602.4 Da
Quantity	0.8 nmol, 3.0 nmol
Concentration	40 µM
Formulation	50 mM Tris pH 7.5, 150 mM NaCl, 10 mM DTT, 10% glycerol
Storage	-80°C, avoid freeze/thaw cycles