UB313: MDM2

LifeSensors UB313 is an HDM2 E3 ubiquitin ligase protein, crucial for regulating the p53 tumor suppressor, widely used in cancer and ubiquitin pathway research.

$574.00

SKU UB-0313-0020 Categories E3 Ubiquitin Ligases, Ubiquitin Ligases and Enzymes Tag E3 ligase

In stock

Product Advantages

Applications

Useful in conjunction with E1 and E2 for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

MDM2 is an E3 (ubiquitin protein ligase) that is a vital regulator of the p53 tumor suppressor protein1. MDM2 can promote tumor formation by targeting tumor suppressor protein p53 for proteasomal degradation. Studies show that MDM2 has the ability to function as a ubiquitin protein ligase for both itself and p53. It has also been shown that MDM2 can mediate its E3-ligase activity in a RING finger-dependent manner. MDM2 is useful in conjunction with E1 and E2 for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Info

Species	Human
Source	E. coli
Tag	N-terminal His6-HA-Smt3
Molecular Weight	68 kDa
Quantity	20 µg
Concentration	Variable
Formulation	1X PBS, 10% glycerol
Storage	-80°C, avoid freeze/thaw cycles