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UB303: Praja1

LifeSensors UB303 (Praja1) is an E3 ubiquitin ligase with a RING-H2 domain, involved in ubiquitin conjugation, essential for protein regulation and cellular processes research.

$529.00

SKU UB-0303-0025 Categories E3 Ubiquitin Ligases, Ubiquitin Ligases and Enzymes Tag E3 ligase

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Praja1 (along with Praja2, 53% identity) is a RING-H2 domain E3 (ubiquitin protein ligase) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E2 enzymes. Substrates for Praja1 include Dlxin-1 (MAGE-D1, human), which regulates Dlx5 dependent transcriptional function (involved in osteoblast differentiation), and ELF and Smad3, which are involved in the TGF-β signaling pathway implicated in gastrointestinal cancers.

Info

Species	Human
Source	E. coli
Tag	His₆-SUMO
Molecular Weight	71 kDa
Quantity	25 µg
Concentration	Variable
Formulation
Storage	-80°C, avoid freeze/thaw cycles

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