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SI9850: NSC-66811

LifeSensors SI9850 (NSC-66811) is a cell-permeable, non-peptide inhibitor of MDM2-p53 interaction (Ki=120nM), activating p53 and p21 in cancer cells for research on tumor suppression.

$250.00

SKU SI-9850-0010 Categories E1-E2-E3 Inhibitors, Small Molecule Modulators and PROTACs

In stock

Product Advantages

Applications

Cell-based studies of MDM2 and p53 function
Comparative studies of new MDM2 or p53 inhibitors

Benefits

Cell-permeable
Non-peptide inhibitor of MDM2-p53 interactions
nM potency

A cell-permeable, non-peptide inhibitor of MDM2-p53 interactions (Ki=120nM). Treatment of cancer cells activates p53 and accumulation of p21, p53, and MDM2. The structure mimics three p53 residues involved in binding to MDM2.

Info

Purity	>97% (TLC, HPLC), NMR (conforms)
Quantity	10 mg
Molecular Weight	340.4 Da
Physical State	White solid
Solubility	DMSO (25mg/ml)
CAS No.	6964-62-1
Storage	4°C, (-20°C Long term). The product can be shipped at room temperature.

Datasheet

Datasheet

Applications

Cell-based studies of MDM2 and p53 function
Comparative studies of new MDM2 or p53 inhibitors

Benefits

Cell-permeable
Non-peptide inhibitor of MDM2-p53 interactions
nM potency

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