Specifications
Brefeldin A is a cell permeable fermentation product from Penicillium brefeldianum. It is a lactone antibiotic and ATPase inhibitor for protein transport with an IC50 of 0.2 μM in HCT 116 cells. Brefeldin A has been widely used as specific inhibitor of protein translocation from endoplasmic reticulum to Golgi. It blocks secretion and prevents the assembly of non-clathrin-coated buds on Golgi cisternae. Brefeldin A also inhibits guanine nucleotide-exchange proteins BIG1 and BIG2, activators of ADP-ribosylation factors. It induces apoptosis independently of p53 and activates sphingomyelin metabolism.
Info
| Purity | >99.0% by HPLC |
| Quantity | 5 mg, 25 mg, 50 mg |
| Molecular Weight | 280.4 g/mol |
| Physical State | Lyophilized powder |
| Solubility | 100 mg/mL in DMSO; or 25 mg/ml in warm ethanol |
| CAS No. | 20350-15-6 |
| Storage | -20°C, avoid freeze/thaw cycles |
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