UB207H: UBE2D2 (UbcH5b, E2-17K2)

LifeSensors UB207H (UBE2D2, UbcH5b) is an E2 ubiquitin-conjugating enzyme essential for substrate ubiquitination, widely used in protein degradation and cell signaling research.

$210.00 – $417.00

SKU UB-207H Categories E2 Ubiquitin Conjugating Enzymes, Ubiquitin Ligases and Enzymes

Nanomole

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Product Advantages

Identify cognate E2/E3 pairs
Characterize upregulation/downregulation of E2 enzymes
Build poly-ubiquitin chains
Characterize ubiquitin chain specificity of E2 enzymes
Analyze expression of E2 enzymes

Benefits

Untagged (native) E2 conjugation enzyme

UBE2D2 (also known as E2-17K2) is an E2 conjugation enzyme that is involved in the ubiquitination of target substrates, along with E1 and E3 enzymes. The UbcH5 family members (including UbcH5a and UbcH5c, 88% and 89% sequence identity with UbcH5b, respectively) are the human homologues of the Sacchromyces cerevisiae UBC4/5 family (~79% sequence identity). Members of the UbcH5 family have been implicated in a number of inflammatory and cancer pathways, including the ubiquitination of p53 (involving the E3 ligase Hdm2) and IκBα (involving the E3 ligase SCF).

Info

Species	Human
Source	E. coli
Tag	His₆
Molecular Weight	17,729.6 Da
Quantity	0.8 nmol, 3.0 nmol
Concentration	40 µM
Formulation	50 mM Tris pH 7.5, 150 mM NaCl, 10 mM DTT, 10% glycerol
Storage	-80°C, avoid freeze/thaw cycles