UB206: MMS2 (yeast)

LifeSensors UB206 is the yeast MMS2 E2 ubiquitin-conjugating enzyme, essential for studying ubiquitination processes and protein regulation in cell biology research.

$221.00 – $487.00

SKU UB-0206 Categories E2 Ubiquitin Conjugating Enzymes, Ubiquitin Ligases and Enzymes

Product Advantages

Identify cognate E2/E3 pairs
Characterize upregulation/downregulation of E2 enzymes
Build poly-ubiquitin chains
Characterize ubiquitin chain specificity of E2 enzymes
Analyze expression of E2 enzymes

Benefits

Untagged (native) E2 conjugation enzyme

MMS2 is an ubiquitin E2 variant (UEV) protein that acts in concert with the E2 enzyme Ubc13. This heterodimeric complex assembles K63-linked polyubiquitin chains for non-degradative ubiquitin signaling pathways (DNA repair, signal transduction). The UEV proteins are structurally similar to E2 enzymes; they display the same fold, yet lack the active site cysteine indicative of E2 enzymes. The Ubc13/MMS2 complex is unique in that it has the ability to form free K63-linked polyubiquitin chains in solution in the absence of an E3.

Info

Species	S. cerevisiae
Source	E. coli
Tag	None
Molecular Weight	15,544.7 Da
Quantity	0.8 nmol, 3.0 nmol
Concentration	40 µM
Formulation	50 mM Tris pH 7.5, 150 mM NaCl, 10 mM DTT, 10% glycerol
Storage	-80°C, avoid freeze/thaw cycles