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Questions about a product, technology or experimental design? Give us a call 610-644-8845.

SI9820: Thalidomide, CRBN Ligase Modulator

LifeSensors SI9820 (Thalidomide) is a CRBN ligase modulator that inhibits E3 ubiquitin ligases, used in research to study protein degradation and ubiquitin pathways. High purity >98%.

Price range: $122.00 through $213.00

Thalidomide binds to the E3 ubiquitin ligase complex formed between cereblon (CRBN), damaged DNA binding protein 1 (DDB1), and Cul4A inhibiting ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Thalidomide initiates its teratogenic effects by binding to CRBN and inhibiting the associated ubiquitin E3 ligase activity. Cell permeable.

Caution: Teratogenic

 

Info

Purity >98% (TLC); NMR (Conforms)
Quantity 100 mg, 200 mg
Molecular Weight 258.2 Da
Physical State White powder
Solubility DMSO (5 mg/ml)
CAS No.
Storage 4°C, (-20°C Long term). Store solutions at -20°C for up to three months. The product can be shipped at room temperature.
  • Inhibition of E3 ubiquitin ligases
  • Cell biology
  • Drug discovery
  • Benefits: cell-permeable

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

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We typically respond within 24 hours

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PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

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