UB401: PINK1

LifeSensors UB401 is recombinant PINK1 from Tribolium castaneum, a serine/threonine kinase that phosphorylates Parkin and ubiquitin, crucial for mitochondrial quality control and Parkinson’s research

$309.00

SKU UB-0401-0050 Categories Neurodegeneration Tools, PINK1 and Parkin Pathway Proteins, Ubiquitin and Neuro-degeneration, Ubiquitin Chains and Derivatives

In stock

Product Advantages

PTEN-induced putative kinase protein 1 (Serine/Threonine kinase PINK1) is an important protein that saves the dysfunction of mitochondria upon application of cellular stress. When the mitochondria is depolarized, PINK stabilizes and gets accumulated. When E3 Ubiquitin Ligase Parkin (PARK2) is brought to the damaged mitochondria, it is activated by PINK1 by phosphorylation at Ser 65 which in turn interacts with ubiquitin that is also phosphorylated at Ser 65. This process is important for removing the damaged mitochondria by mitophagy (selective autophagy) by mediating activation and translocation of PARK2. Recombinant human PINK1 effectively phosphorylates recombinant Parkin, mono-Ubiquitin, and poly-Ubiquitin chains. It specifically phosphorylates both Parkin and Ubiquitin at serine 65. This recombinant protein contains an MBP tag.

Info

Species	T. castaneum (red flour beetle)
Source	E. coli
Tag	MBP
Molecular Weight	106 kDa
Quantity	50 µg
Concentration	Variable
Formulation
Storage	-80°C, avoid freeze/thaw cycles