Specifications
E6-AP (E6-associated protein) is an E3 (ubiquitin protein ligase) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E2 enzymes. It is a HECT domain E3 containing an active site cysteine that accepts a charged ubiquitin from the ubiquitin-E2 thioester complex. E6-AP has been linked to the neurodevelopmental disorder, Angelman syndrome. Additionally, the oncoprotein E6 of human papillomaviruses (HPV) utilizes E6-AP to target numerous cellular proteins for degradation including the tumor suppressor protein p53.
Info
| Species | Human |
| Source | E. coli |
| Tag | None |
| Molecular Weight | 101 kDa |
| Quantity | 25 µg |
| Concentration | Variable |
| Formulation | 20 mM Hepes pH7.5, 150mM NaCl, 10% Glycerol |
| Storage | -80°C, avoid freeze/thaw cycles |
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