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Questions about a product, technology or experimental design? Give us a call 610-644-8845.

UB101: UBE1

LifeSensors UB101 is a purified human UBE1 enzyme, the ubiquitin-activating enzyme essential for initiating ubiquitination in protein regulation and degradation studies.

$287.00

In stock

In stock

UBE1, the ubiquitin activating enzyme, is the first enzyme in the pathway for conjugation of ubiquitin to target substrates through a ubiquitin-protein isopeptide bond. The C-terminal glycine of a ubiquitin (G76) is initially adenylated in an ATP dependent manner, followed by activation through transfer to the active site cysteine of UBE1, forming a ubiquitin-UBE1 thiolester. With the help of the other enzymes in the ubiquitin conjugation pathway (E2/E3 enzymes) ubiquitin is then transferred to a specific lysine on a target substrate.

Info

Species Human
Source E. coli
Tag Untagged
Molecular Weight 118 kDa
Quantity  50 µg
Concentration Variable
Formulation 50mM Tris pH 8.0, 100mM NaCl, 10% glycerol
Storage -80°C, avoid freeze/thaw cycles

Applications

  • Investigation of DUB linkage specificity

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

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