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UPS Inhibitor

SI9619: PR-619

LifeSensors SI9619 (PR-619) is a cell-permeable, reversible, non-selective inhibitor of deubiquitinases and ubiquitin-like isopeptidases, inducing ubiquitin and SUMO protein accumulation with IC50 of 5-20 µM for cell biology and drug discovery research.

$100.00 – $483.00

SKU SI-9619 Categories , , , , , Tag
  • Non-specific inhibition of isopeptidases
  • Cell biology
  • Preparation of cell/tissue lysates
  • Drug discovery
  • Benefits: cell-permeable
PR-619 is a non-selective, reversible inhibitor of deubiquitinases/deubiquitylases (DUBs) and ubiquitin-like isopeptidases. PR-619 inhibits many deubiquitinating enzymes in the 5-20 µM range. Additionally, PR-619 is cell-permeable and treatment of cells results in the accumulation of both ubiquitin and sumo-conjugated proteins.

Info

Purity ≥ 95% (RP-HPLC)
Quantity 5 mg; 25 mg
Molecular Weight 223.28 Da; measured M+H+ = 224.11
Physical State Dry powder
Solubility > 5 mg/mL in DMSO
CAS No.
Storage 4 °C, with long term storage down to -20°C. Product can be shipped at room temperature.
This product has been cited 1 time.
  • Non-specific inhibition of isopeptidases
  • Cell biology
  • Preparation of cell/tissue lysates
  • Drug discovery
  • Benefits: cell-permeable

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