SI280: Ubiquitin, Biotinylated (all lysines unmodified)

LifeSensors’ SI280 is biotinylated ubiquitin with all lysines unmodified, ideal for studying protein ubiquitination and post-translational modifications in cellular research

$335.00

In stock

Post-translational modification of proteins by ubiquitin (Ub) is a key regulatory process that impacts almost all cellular functions. Ubiquitylation occurs through isopeptide linkage between the C-terminus of Ub and the ε-amino group of a lysine (Lys) residue on the target substrate. Ub itself has seven Lys residues (6, 11, 27, 29, 33, 48, and 63), any of which can participate in further ubiquitylation, generating polyUb chains. LifeSensors’ biotinylated ubiquitin carries a single biotin molecule attached at a defined location and unlike other biotinylated ubiquitins, avoids modification of the N-terminus, C-terminus or any of the seven Lys side chains. Therefore, this biotinylated ubiquitin has all lysines available for conjugation and can be incorporated into polyubiquitin chains of any linkage type.

Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	9,106.98 Da
Quantity	100µg
Concentration	Variable
Formulation	PBS
Storage	-80°C, avoid freeze/thaw cycles

Datasheet

In vitro ubiquitin conjugation
Determination of the activity of ubiquitin conjugating enzymes
Unmodified N-terminus, C-terminus
All seven lysine residues are available for conjugation and can be incorporated into polyubiquitin chains of any linkage type

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All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

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SI280: Ubiquitin, Biotinylated (all lysines unmodified)

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