SI0102-5µg (panel) Linear (Ub2) di-ubiquitin

SI0604: K6-Linked Tetra-Ubiquitin

LifeSensors SI0604 is a high-purity K6-linked tetra-ubiquitin protein used in biochemical research to study ubiquitination and protein regulation pathways.

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Product Advantages

• Investigation of ubiquitin chain specificity and selectivity
• Studies on the role of ubiquitin chains in protein degradation pathways (e.g., proteasomal and autophagic degradation)
• Analysis of ubiquitin-mediated signaling pathways and cellular responses
• Structural studies to elucidate the architecture and dynamics of ubiquitin chains
• Screening assays to identify modulators of ubiquitin chain assembly and disassembly processes

K6-linked ubiquitination is traditionally associated with mitophagy and also a main contributor to the DNA damage response. These chain types are also involved in protein stabilization and other non-degradative processes. K6 Tetra-Ubiquitin is a tetrameric chain of wild-type ubiquitin, wherein ubiquitin monomers are enzymatically linked together via an isopeptide bond between Lysine 6 and the C-terminal Glycine. Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	34233 Da (depending on degree of phosphorylation)
Quantity	Variable
Concentration	Variable
Formulation	20 mM Tris pH 7.5, 150 mM NaCl
Storage	-80°C, avoid freeze/thaw cycles