PR1105: ISG15-CHOP2 Reporter System

SKU PR-1105-0375 Categories CHOP2 Reporter Assays, DUBs

The ISG15-CHOP2-Reporter DeISGylation Assay uses an ISG15-reporter fusion that is inactive until cleaved by an isopeptidase. Cleavage activates the reporter, which acts on its substrate, producing a signal proportional to isopeptidase activity.

$1,495.00

In stock

The ISG15-CHOP2-Reporter DeISGylation Assay consists of ISG15 fused to a reporter enzyme, as well as a separate reagent substrate for the reporter enzyme. When fused to ISG15, the reporter is rendered catalytically inactive. Following cleavage of the ISG15-reporter system by the isopeptidase, the free (and now active) reporter subsequently acts upon its substrate. Thus, in the coupled assay, the signal generated by cleavage of the reporter enzyme’s substrate is a quantitative measure of isopeptidase activity. This product is protected by one or more US or Foreign patents. Please read the Limited Use Label License to learn more. By purchasing this product, the purchaser agrees to comply with these terms.

ISG15-CHOP2-Reporter System: 1 x 375μL (4μM)
PLpro (Control Isopeptidase): 2 x 10μL (2μM)
Reporter Substrate 2: 1 x 30μL (25μM)
Control Fluorophore 2: 1 x 20μL (1mM)

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Storage

-80° C, avoid freeze/thaw cycles

Manual

Demonstration of novel deISGylating activity
High-throughput screening (HTS) for antagonists or agonists of deISGylating activity

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

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PR1105: ISG15-CHOP2 Reporter System

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