PC1003: VH298

VH298 is a cell permeable high-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM). It blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating a hypoxic response. Results in time- and concentration-dependent accumulation of hydroxylated HIF-α, and upregulates mRNA and protein levels of HIF target genes.

Info

Purity	>98%
Quantity	5 mg, 10 mg, 25 mg
Molecular Weight	523.65 g/mol
Physical State	Lyophilized white powder
Solubility	50 mg/mL in DMSO; 50 mg/mL in Ethanol
CAS No.	2097381-85-4
Storage	solutions at -20°C or -80°C; desiccated at -20°C, avoid freeze/thaw cycles