Questions about a product, technology or experimental design? Give us a call 610-644-8845
Questions about a product, technology or experimental design? Give us a call 610-644-8845.

K6 Tetra-Ubiquitin (Ub4) Wild-Type

LifeSensor’s K6 Tetra-Ubiquitin (Ub4) Wild-Type is a high-purity, enzymatically linked tetra-ubiquitin chain for studying mitophagy, DNA repair, and immune response pathways.

This product is currently out of stock and unavailable.

This product is currently out of stock and unavailable.

Mitophagy (the autophagic processing of damaged mitochondria) via Parkin activation is mainly promoted by K6 and K63 linked chains.  K6-linked ubiquitination is also a main contributor to the DNA damage response and acts as a DNA-binding enhancer during the innate immune system response.  These chain types are also involved in protein stabilization and other non-degradative processes. These tetra-ubiquitin chains are generated from the enzymatic linkage of wild-type ubiquitin through lysine 6.

Product Information

Purity ≥ 70% SDS-PAGE and Mass Spectrometry
Molecular Weight 34202 Da
Physical State Liquid
Quantity 25 µg or 50 µg
Solubility >30 mg/ml
Storage -80°C, avoid freeze/thaw cycles
 

Application

• To investigate enzymes that cleave this specific peptide linkage between two ubiquitin molecules.
• To better understand the mechanisms of ubiquitin-activating (E1) or ubiquitin-conjugating (E2) enzymes, ubiquitin-associated domains (UBA), or ubiquitin-interacting motifs (UIMs) among others.

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

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PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

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