Specifications
USP30 (Ubiquitin Specific Protease 30) is a deubiquitinase involved in the regulation of mitophagy. It is attached to the outer mitochondrial membrane by insertion of a transmembrane domain (residues 36-56). It removes ubiquitin from target proteins ubiquitinated by the E3 Ligase Parkin (PARK2). This form of USP30 has been engineered to increase it stability while retaining the cleavage preference for K6-linked ubiquitin chains over other chains. USP30 shows reduced efficiency to cleave phosphorylated ubiquitin chains.
Info
| Species | |
| Source | |
| Tag | His6 + SUMO |
| Molecular Weight | 51 kDa |
| Quantity | 25 or 50 µg |
| Concentration | Variable |
| Formulation | |
| Storage | -80°C, avoid freeze/thaw cycles |
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