SI9780: Epoxomicin/BU-4061T, proteasome inhibitor

LifeSensors SI9780 (Epoxomicin/BU-4061T) is a highly potent, selective proteasome inhibitor that blocks all three proteasome activities, used in research on protein degradation and drug discovery.

$250.00

SKU SI-9780-0100 Categories Proteasome Inhibitors, Small Molecule Modulators and PROTACs

In stock

Product Advantages

Applications

Inhibition of all three proteasome catalytic activities.
Elevation of protein levels for proteins that are ubiquityated in particular cell lines.
Cell-based and in vitro studies of proteasome function

One of the most potent and selective proteasome inhibitors, Epoxomycin inhibits all three activities of the proteasome. Epoxomicin (100 nM) results in a 30-fold increase in the levels of p53 protein, a known target of the proteasome, in HUVECs. Epoxomicin (10 μM) results in the accumulation of ubiquitinated proteins in HeLa cells. Epoxomicin (10 μM) inhibits IκBα degradation by 10-fold in HeLa cells. Need Assistance? We’re happy to help! Contact our technical support team at customerservice@lifesensors.com.

Info

Purity	>99.0% by HPLC
Quantity	100 ug
Molecular Weight	554.72 Da
Physical State	Lyophilized powder
Solubility	DMSO (10 mg/mL)
CAS No.	134381-21-8
Storage	4°C, (-20°C Long term). The product can be shipped at room temperature.

Datasheet

Datasheet

Applications

Inhibition of all three proteasome catalytic activities.
Elevation of protein levels for proteins that are ubiquityated in particular cell lines.
Cell-based and in vitro studies of proteasome function