UB304: E6AP

LifeSensors UB304 is a high-purity human recombinant E6AP (E6-associated protein) E3 ubiquitin ligase used in ubiquitination research and protein degradation studies.

$502.00

SKU UB-0304-0025 Categories E3 Ubiquitin Ligases, Ubiquitin and Neuro-degeneration Tag E3 ligase

In stock

Product Advantages

Applications

Typical enzyme concentration of 100 nM – 5 µM is used for in vitro conjugation, depending on conditions.

E6-AP (E6-associated protein) is an E3 (ubiquitin protein ligase) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E2 enzymes. It is a HECT domain E3 containing an active site cysteine that accepts a charged ubiquitin from the ubiquitin-E2 thioester complex. E6-AP has been linked to the neurodevelopmental disorder, Angelman syndrome. Additionally, the oncoprotein E6 of human papillomaviruses (HPV) utilizes E6-AP to target numerous cellular proteins for degradation including the tumor suppressor protein p53.

Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	101 kDa
Quantity	25 µg
Concentration	Variable
Formulation	20 mM Hepes pH7.5, 150mM NaCl, 10% Glycerol
Storage	-80°C, avoid freeze/thaw cycles