DB520: USP20

USP20 (Ubiquitin Specific Protease 20, VDU2) was identified by its homology to USP33 and binds competitively to the substrate recognition beta-domain of pVHL, a region commonly mutated in patients with pVHL disease. Furthermore, USP20 has been shown to be ubiquitinated by the pVHL E3 ligase complex in vitro and in cells. The enzyme acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2).

Info

Species	Human
Source	Insect
Tag	His6
Molecular Weight	105 kDa
Quantity	25 µg
Concentration	Variable
Formulation	50 mM Tris pH 8.0, 150 mM NaCl, 1 mM EDTA, 5 mM DTT, 10% glycerol
Storage	-80°C, avoid freeze/thaw cycles