Questions about a product, technology or experimental design? Give us a call 610-644-8845
Questions about a product, technology or experimental design? Give us a call 610-644-8845.

UB319: Delta UBL Parkin E3 Ligase

LifeSensors UB319: Delta UBL Parkin E3 Ligase enhances research on neurodegenerative diseases by targeting and modulating Parkin E3 ligase activity for therapeutic insights.

$795.00

In stock

In stock

Encoded by the PARK2 gene, the E3 ligase Parkin is part of the multi-protein E3 complex that encodes substrate proteins for degradation in the Ubiquitin-Proteosome Pathway. The precise function of this protein is unknown; however, mutations in this gene are known to cause a familial form of Parkinson’s disease known as autosomal recessive juvenile Parkinson’s disease (AR-JP). Parkin is described to be necessary for mitophagy (autophagy of mitochondria). Phosphorylation of Parkin’s UBL at Ser65 by PINK1 kinase activates Parkin.   Info
Species Human
Source E. coli
Tag His10-SUMO
Molecular Weight 55 kDa
Quantity 25 µg
Concentration Variable
Formulation 20 mM Tris pH 7.5, 150 mM NaCl, 10% Glycerol
Storage -80°C, avoid freeze/thaw cycles
  • For use in investigating and research of the Parkin and PINK1 pathway of mitophagy and/or drug discovery.

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