SI4804P: K48-Linked Tetra Ubiquitin (Phosphorylated)

K48 chains traditionally play a role in proteasomal degradation pathways. Phospho-ubiquitin chains represent a specialized class of polyubiquitin characterized by phosphorylation at Serine 65 and play a central role in mitophagy signaling pathways. K48 Tetra-Ubiquitin (phosphorylated) is a tetrameric chain of wild-type ubiquitin, wherein ubiquitin monomers are linked together via an isopeptide bond between Lysine 48 and the C-terminal Glycine. The chains are then enzymatically phosphorylated at the Ser65 position.

Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	34313-34553 Da (depending on degree of phosphorylation)
Quantity	Variable
Concentration	Variable
Formulation	20 mM Tris pH 7.5, 150 mM NaCl
Storage	-80°C, avoid freeze/thaw cycles