UB319: Delta UBL Parkin E3 Ligase

Encoded by the PARK2 gene, the E3 ligase Parkin is part of the multi-protein E3 complex that encodes substrate proteins for degradation in the Ubiquitin-Proteosome Pathway. The precise function of this protein is unknown; however, mutations in this gene are known to cause a familial form of Parkinson’s disease known as autosomal recessive juvenile Parkinson’s disease (AR-JP). Parkin is described to be necessary for mitophagy (autophagy of mitochondria). Phosphorylation of Parkin’s UBL at Ser65 by PINK1 kinase activates Parkin.   Info

Species	Human
Source	E. coli
Tag	His10-SUMO
Molecular Weight	55 kDa
Quantity	25 µg
Concentration	Variable
Formulation	20 mM Tris pH 7.5, 150 mM NaCl, 10% Glycerol
Storage	-80°C, avoid freeze/thaw cycles