SI6303: K63-Linked Tri-Ubiquitin

SKU SI-6303-0100 Categories Ubiquitin Chains, Ubiquitin Chains and Derivatives

LifeSensors’ SI6303 is a human K63-linked tri-ubiquitin protein used in biochemical research, expressed in E. coli, with a molecular weight of ~25.7 kDa and supplied at 100µg

$414.00

In stock

Polyubiquitination of target proteins through K63 has recently become the focus of intense study. The topology of this linkage type is quite different from polyubiquitin linked through lysine 48. Modification of proteins by K63-linked polyubiquitination has been implicated in, among other cellular processes, the regulation of the DNA damage response, endosomal sorting, autophagy of misfolded/aggregated proteins, neurodegeneration, and signal transduction. These tri-ubiquitin chains are generated from the enzymatic linkage of wild-type ubiquitin through lysine 63. The most distal ubiquitin contains an arginine substitution for the lysine at position 63, limiting chain length.

Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	25,686.5 Da
Quantity	100µg
Concentration	Variable
Formulation	20 mM Tris pH 7.5, 150 mM NaCl, 1 mM EDTA
Storage	-80°C, avoid freeze/thaw cycles

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SI6303: K63-Linked Tri-Ubiquitin

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