SI6302P: K63-Linked Di-Ubiquitin (Phosphorylated)

SKU SI-6302P-0025 Categories All, Phosphorylated Ubiquitin Chains, Ubiquitin and Neuro-degeneration, Ubiquitin Chains, Ubiquitin Chains and Derivatives, Ubiquitin Derivatives

LifeSensors SI6302P is a phosphorylated K63-linked di-ubiquitin protein from E. coli, used for studying ubiquitination and signaling pathways in cell biology research.

$695.00

K63 chains traditionally play a role in intracellular signaling, trafficking, and autophagy. Phospho-ubiquitin chains represent a specialized class of polyubiquitin characterized by phosphorylation at Serine 65 and play a central role in mitophagy signaling pathways. K63 Di-Ubiquitin (phosphorylated) is a dimeric chain of wild-type ubiquitin, wherein ubiquitin monomers are linked together via an isopeptide bond between Lysine 63 and the C-terminal Glycine. The chains are then enzymatically phosphorylated at the Ser65 position. Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	17219-17299 Da (depending on degree of phosphorylation)
Quantity	25µg
Concentration	Variable
Formulation	20 mM Tris pH 7.5, 150 mM NaCl
Storage	-80°C, avoid freeze/thaw cycles

Datasheet

Investigation of phosphoubiquitin chain specificity and selectivity
Studies on the role of phosphoubiquitin chains in protein degradation pathways (e.g., proteasomal and autophagic degradation)
Analysis of phosphoubiquitin-mediated signaling pathways and cellular responses
Structural studies to elucidate the architecture and dynamics of phosphoubiquitin chains
Screening assays to identify modulators of phosphoubiquitin chain assembly and disassembly processes

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SI6302P: K63-Linked Di-Ubiquitin (Phosphorylated)

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