SI4803P: K48-Linked Tri-Ubiquitin (Phosphorylated)

LifeSensors SI4803P is a phosphorylated K48-linked tri-ubiquitin protein used for studying ubiquitin signaling and proteasomal degradation pathways in research.

$795.00

SKU SI-4803P-0025 Categories All, Neurodegeneration Tools, Phospho-Ubiquitin Chains and Derivatives, Phosphorylated Ubiquitin Chains, Ubiquitin and Neuro-degeneration, Ubiquitin Chains, Ubiquitin Chains and Derivatives Tag Degradation

Product Advantages

Application

Investigation of phosphoubiquitin chain specificity and selectivity
Studies on the role of phosphoubiquitin chains in protein degradation pathways (e.g., proteasomal and autophagic degradation)
Analysis of phosphoubiquitin-mediated signaling pathways and cellular responses
Structural studies to elucidate the architecture and dynamics of phosphoubiquitin chains

K48 chains traditionally play a role in proteasomal degradation pathways. Phospho-ubiquitin chains represent a specialized class of polyubiquitin characterized by phosphorylation at Serine 65 and play a central role in mitophagy signaling pathways. K48 Tri-Ubiquitin (phosphorylated) is a trimeric chain of wild-type ubiquitin, wherein ubiquitin monomers are linked together via an isopeptide bond between Lysine 48 and the C-terminal Glycine. The chains are then enzymatically phosphorylated at the Ser65 position

Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	25766-25926 Da (depending on degree of phosphorylation)
Quantity	Variable
Concentration	Variable
Formulation	20 mM Tris pH 7.5, 150 mM NaCl
Storage	-80°C, avoid freeze/thaw cycles

Datasheet

Datasheet

Application

Investigation of phosphoubiquitin chain specificity and selectivity
Studies on the role of phosphoubiquitin chains in protein degradation pathways (e.g., proteasomal and autophagic degradation)
Analysis of phosphoubiquitin-mediated signaling pathways and cellular responses
Structural studies to elucidate the architecture and dynamics of phosphoubiquitin chains